1.專題演講:Human Cellular Prostatic Acid Phosphatase as a Novel Prostate Cancer Tumor


The inactivation of tumor suppressor genes (TSGs) plays a vital role in the progression of human cancers. Nevertheless, those ubiquitous TSGs have been shown with limited roles in various stages of diverse carcinogenesis. Investigation on identifying unique TSG, especially for early stage of carcinogenesis, is imperative. As such, the search for organ-specific TSGs has emerged as a major strategy in cancer research. Prostate cancer (PCa) has the highest incidence in solid tumors in US males. Cellular prostatic acid phosphatase (cPAcP) is a prostate-specific differentiation antigen. Despite intensive studies over the past several decades on PAcP as a PCa biomarker, the role of cPAcP as a PCa-specific tumor suppressor has only recently been emerged and validated. The mechanism underlying the pivotal role of cPAcP as a prostate-specific TSG is, in part, due to its function as a protein tyrosine phosphatase (PTP) as well as a phosphoinositide phosphatase (PIP), an apparent functional homologue to Phosphatase and tensin homolog (PTEN) in PCa cells. This review is focused on discussing the function of this authentic prostate-specific tumor suppressor and the mechanism behind the loss of cPAcP expression leading to prostate carcinogenesis. We review other phosphatases’ roles as TSGs which regulate oncogenic PI3K signaling in PCa and discuss the functional similarity between cPAcP and PTEN in prostate carcinogenesis.

 

2. 參加對象:高雄醫學大學全校師生
3. 參與人數:50人
4. 活動時間:104年10月7日(星期三)
                      13:45-14:00報到
                      14:00-14:05 開場致詞
                      14:05-15:20 演講
                      15:20-15:30 Q & A
5. 活動地點:勵學大樓第一會議室
6. 講員:林明豐教授 Ming-Fong Lin, Ph.D.
7.主辦:傳染病與癌症研究中心、醫藥暨應用化學系

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