演講題目: CISD2 Mediates Life Span in Mammals
1. 1. 演講摘要：The CISD2 gene, which is an evolutionarily conserved novel gene, encodes a transmembrane protein primarily associated with the mitochondrial outer membrane. Previously we have shown that mouse Cisd2 deficiency shortens lifespan resulting in premature aging. Additionally, an age-dependent decrease in mouse Cisd2 expression has been detected during normal aging. Recently, we demonstrated that a persistent level of Cisd2 achieved by transgenic expression in mice extends their median and maximum lifespan without any apparent deleterious side effects. Cisd2 also ameliorates age-associated degeneration of the skin, skeletal muscles and neurons. Moreover, Cisd2 protects mitochondria from age-associated damage and functional decline as well as attenuating the age-associated reduction in whole-body energy metabolism. These results suggest that Cisd2 is a fundamentally important regulator of lifespan, and provide an experimental basis for exploring the candidacy of CISD2 in human longevity.
4. 活動時間：105年1月20日(星期三) 上午10:00 ~ 12:00
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