演講題目: CISD2 Mediates Life Span in Mammals

1.  1. 講摘要:The CISD2 gene, which is an evolutionarily conserved novel gene, encodes a transmembrane protein primarily associated with the mitochondrial outer membrane. Previously we have shown that mouse Cisd2 deficiency shortens lifespan resulting in premature aging. Additionally, an age-dependent decrease in mouse Cisd2 expression has been detected during normal aging. Recently, we demonstrated that a persistent level of Cisd2 achieved by transgenic expression in mice extends their median and maximum lifespan without any apparent deleterious side effects. Cisd2 also ameliorates age-associated degeneration of the skin, skeletal muscles and neurons. Moreover, Cisd2 protects mitochondria from age-associated damage and functional decline as well as attenuating the age-associated reduction in whole-body energy metabolism. These results suggest that Cisd2 is a fundamentally important regulator of lifespan, and provide an experimental basis for exploring the candidacy of CISD2 in human longevity.

2. 參加對象:高雄醫學大學全校師生

3. 參與人數:50人    

4. 活動時間:105年1月20日(星期三)  上午10:00 ~ 12:00

5. 活動地點:勵學大樓3樓半視聽中心

6. 活動議程:     

9:45 ~ 10:00  報到

10:00 ~ 10:10 開場致詞

10:10 ~ 11:40 專題演講

11:40 ~ 12:00  Q&A時間

7.講員:陽明大學生命科學系暨基因體科學研究所蔡亭芬教授

8.報名網址:

https://docs.google.com/forms/d/1DDy8p1UMG8olwlNrgCgFQF8BUzVfUd1w17ljcDn4mR8/edit

9.聯絡人:陳冠璇    分機:2559#11   e-mail:khchen@kmu.edu.tw

◎本活動教師成長計分(研究成長類別)成長(1)分

◎現場紙本簽到退

歡迎大家踴躍參加!!

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