Glycobiology of Immune and Inflammatory Responses
One area of research that has advanced significantly and become a major focus of glycobiology is functional glycomics, which is to define the concerted and regulated action of glycan-binding proteins (GBPs). GBPs function by recognizing glycans on the cell surfaces and extracellular matrices. Currently, C-type lectins (such as selectins), C-type lectin receptors (Clec), Siglecs, and galectins have gained most attention. These proteins have been shown to be involved in inflammation and immunity, as well as many other physiological processes and pathogenesis of a variety of diseases. Importantly, many of them have been identified as biomarkers of diseases and therapeutic targets.
Galectins are a family of -galactoside-binding proteins, which differ from other glycan-binding proteins by not having a classical signal sequence. They are in fact present in the cytosol and can be translocated to the nucleus, although they can still be secreted through an as yet undefined mechanism and exist in the extracellular space. A number of galectins have been shown to play a role in various immune and inflammatory responses. A key challenge is to determine whether they function extracellularly or intracellularly in an organism. Importantly, they can function intracellularly in a glycan-independent fashion. However, an important recent development is intracellular galectins may act as “danger signal sensors” by detecting glycans in damaged intracellular organelles.
4. 活動時間：107年9月13日(星期四) 上午9:50～11:15
Time: September 13, 2018, 09:50～11:15
09:50~10:00 報到 Registration
10:00~11:00 專題演講 Special lecture
Venue: Audio-visual center, Li-Hsueh Building,Kaohsiung Medical University, Kaohsiung City, Taiwan
Fu-Tong Liu, MD, PhD
7. 報名網址: https://docs.google.com/forms/d/1Ne55pvmu8Ky-fh99BmH1gP2hAQ7Bn1zM_PkNm52ZM1Y/edit