1.活動主題:深耕計畫 培育特色研發人才系列活動-專題演講()

Glycobiology of Immune and Inflammatory Responses

One area of research that has advanced significantly and become a major focus of glycobiology is functional glycomics, which is to define the concerted and regulated action of glycan-binding proteins (GBPs). GBPs function by recognizing glycans on the cell surfaces and extracellular matrices. Currently, C-type lectins (such as selectins), C-type lectin receptors (Clec), Siglecs, and galectins have gained most attention. These proteins have been shown to be involved in inflammation and immunity, as well as many other physiological processes and pathogenesis of a variety of diseases. Importantly, many of them have been identified as biomarkers of diseases and therapeutic targets.

Galectins are a family of -galactoside-binding proteins, which differ from other glycan-binding proteins by not having a classical signal sequence. They are in fact present in the cytosol and can be translocated to the nucleus, although they can still be secreted through an as yet undefined mechanism and exist in the extracellular space. A number of galectins have been shown to play a role in various immune and inflammatory responses. A key challenge is to determine whether they function extracellularly or intracellularly in an organism. Importantly, they can function intracellularly in a glycan-independent fashion. However, an important recent development is intracellular galectins may act as “danger signal sensors” by detecting glycans in damaged intracellular organelles.

2. 參加對象:高雄醫學大學師生、研究人員

3. 參與人數:50

4. 活動時間:107913(星期四) 上午9:5011:15

Time: September 13, 2018, 09:5011:15

09:50~10:00 報到 Registration

10:00~11:00 專題演講 Special lecture

11:00~11:15 Q&A

5. 活動地點:勵學大樓3樓半視聽中心

Venue: Audio-visual center, Li-Hsueh Building,Kaohsiung Medical University, Kaohsiung City, Taiwan

6. 講員:劉扶東院士(中研院通信研究員兼副院長)

Fu-Tong Liu, MD, PhD

7. 報名網址: https://docs.google.com/forms/d/1Ne55pvmu8Ky-fh99BmH1gP2hAQ7Bn1zM_PkNm52ZM1Y/edit

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